Physiology and healing dynamics of chronic cutaneous wounds
Stadelmann WK, Digenis AG, Tobin GR.
Division of Plastic and Reconstructive Surgery, University of Louisville, Kentucky 40292, USA.
ABSTRACT: In the last few decades, a great deal of progress has been made in understanding the cellular and biochemical interplay that comprises the normal wound healing response. This response is a complex process involving intricate interactions among a variety of different cell types, structural proteins, growth factors, and proteinases. The normal wound repair process consists of three phases–inflammation, proliferation, and remodeling–that occur in a predictable sequence and comprise a series of cellular and biochemical events. A review of the biochemical and physiologic processes that regulate wound healing and the cascade of cellular events that gives rise to the healing process is presented here.
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